The Integrated Molecular Structure Education and Research Center (IMSERC) facility performs a full range of chemical analyses. Such analyses include qualitative composition determination, quantitative analysis, and molecular structure determination. The most commonly used techniques are NMR spectroscopy, mass spectrometry, optical spectroscopy, trace metals analysis and single crystal X-Ray crystallography. For more information about this facility, click here.
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Equipment / Supplies Available at this Facility
Equipment / Supplies Available at this Facility:
Sometimes the needs of your research exceed the capabilities of our walk-up instrumentation. Perhaps you need a different type of ionization or you need separation methods developed for your synthetic product. For usage outside of the normal bounds of our walk-up instruments and submission process, please consult the IMSERC staff. We are happy to meet with you to discuss the needs of your project, the capabilities you require, the data you have already generated, and how to best achieve your research goals. We will work with you to develop your project and train you in the necessary advanced operations of the instrumentation. If we do not have the instrumentation you require here on site, we will seek out the resources through our connections through Argonne National Labs, the Chicago Biomedical Consortium and beyond. Our goal is to provide you with one location where you can come for all your mass spectrometry research concerns. Please do not hesitate to contact IMSERC staff for project and methods development.
Solution NMR is the only technique to get a three-dimensional structure for a protein or protein ligand complex in its native functional state. In addition to providing insights about their three-dimensional structures and functions, it can also be employed to probe the protein or enzyme active sites and folding changes associated with enzyme activation.
Full structure determination provides atomic coordinates in three-dimensional space that can be used for publication purposes in peer-review journals. Coordinates and other structural metrics will be provided in a Crystallographic Information File (CIF) along with a report which contains refinement details and references.